Directory of funded grants

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551 results found

Brain channelopathies: target validation and novel therapeutic strategies

  • Program Type

    Team grants

  • Area of research

    Neurotechnology

  • Disease Area

    Other

  • Competition

    2012 MIRI Team Grants

  • Province

    British Columbia

  • Start Date

    2014

  • Total Grant Amount

    $1,425,000

  • Health Canada Contribution

    $712,500

Project Overview

The entry of calcium ions into cells is mediated by a class of protein (called calcium  channels) that responds to electrical signals by opening of a calcium-selective pore.  Calcium channels are involved in a large number of physiological processes including  muscle contraction, hormone secretion and nerve cell communication in the…

Uncovering the pathological processes underlying neuronal dysfunction and loss in models of Parkinson’s disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Brain Repair Program

  • Province

    Ontario

  • Start Date

    2011

  • Total Grant Amount

    $1,320,000

  • Health Canada Contribution

    $660,000

Project Overview

The aims of the proposal were to examine the mechanism of how dopamine neurons degenerate in Parkinson (PD) animal models. The work was centered on three recessive genes linked to PD: Pink1, DJ-1, and Parkin. Previous work published by the team had indicated that these genes are associated with mitochondrial…

Human MiniPromoters for Restricted Expression of Ocular Gene Therapy

  • Program Type

    Platform grants

  • Area of research

    Sensory system

  • Disease Area

    Other

  • Competition

    CQDM - Brain Canada - Focus on Brain

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $1,496,062

  • Health Canada Contribution

    $637,136

Project Overview

The purpose of this project is to develop promoters. Promoters are pieces of DNA, which act as switches to turn genes on and off. Such promoters are important tools for drug companies working on developing gene-based therapies; known as gene therapies. These are a type of biological therapy, somewhat like…

Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Innovation Grants

  • Province

    Saskatchewan

  • Start Date

    2017

  • Total Grant Amount

    $195,968

  • Health Canada Contribution

    $97,984

Project Overview

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy. Glioblastomas, aggressive brain cancers, are treated by surgical removal of the tumour followed by radiation and chemotherapy. A molecule found on the surface of cells…

Molecular characterization of transcriptional repressor capicua in GBM

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Innovation Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $196,000

  • Health Canada Contribution

    $98,000

Project Overview

Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options. A better understanding of the molecular underpinnings of glioma is required to find new and better treatments. The goal of this study is to investigate the function of a protein that turns…