721 results found
Toxicity Pathways and Catalytic Potential of Cu-Containing AB Oligomers
Project Overview
The protein fragment beta-amyloid has long been a key suspect in Alzheimer’s disease. Beta-amyloid molecules have a normal function, but in Alzheimer’s they form clumps called oligomers and plaques that may be toxic to nerve cells. Recent studies indicate that beta-amyloid is more likely to form toxic clumps when it…
Project Complete
See the project and researchersPathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery
Project Overview
In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS. One of the first discoveries about C9ORF72 was that it…
Project Complete
See the project and researchersA patient-derived iPSC platform of disease relevant cell models for biological studies
Project Overview
One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it possible to create essentially any cell type in the body using any other as a starting point. In ALS, iPSCs provide the opportunity to take…
Project Ongoing
See the project and researchersDecoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics
Project Overview
ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly understood…
Project Complete
See the project and researchersInvestigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS
Project Overview
Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Furthermore, one of the emerging areas of interest for environmental exposure is the gastrointestinal tract and how dietary exposures might…