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Discovery of transcriptomic biomarkers and epigenetic therapeutic targets for c9ALS and sALS
Project Overview
Dr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. During this time, Dr. Belzil pursued a better understanding of the genetics behind familial/hereditary ALS and…
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See the project and researchersCharacterization of MATR3 Mutations Associated with ALS
Project Overview
For this project, Dr. Park will examine how abnormalities in RNA binding proteins (RBPs) – in particular, one called Matrin 3 (MATR3) – can lead to ALS. MATR3 was discovered to be a genetic cause of ALS in 2014 and has yet to be studied in any detail. By creating…
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See the project and researchersMechanisms of glutamatergic neuronal dysfunction in genetic models of ALS
Project Overview
This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction. Recent evidence from a number of labs has indicated that errors in neurotransmission of signals might be one of the first pathological effects in…
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See the project and researchersMechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis
Project Overview
This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the…
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See the project and researchersRegulation of the stress granule proteome and transcriptome by TDP-43 in ALS: biomarkers and therapeutic targets
Project Overview
When cells are under stress, one of the reactions is to form tiny clumps called stress granules that protect important genetic information while protective mechanisms kick in. Toxicity in ALS might arise from both an abnormal ability to properly form stress granules and/or a failure to disassemble stress granules after…