687 results found
Molecular characterization of transcriptional repressor capicua in GBM
Project Overview
Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options. A better understanding of the molecular underpinnings of glioma is required to find new and better treatments. The goal of this study is to investigate the function of a protein that turns…
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See the project and researchersIntegrative discovery of ion channels as drug targets in glioblastoma
Project Overview
Ion channel (IC) proteins are known to be involved in different human diseases such as heart and brain disorders. There are many drugs that activate or inactivate ICs and they are used to treat patients with these diseases. However, less has been known about the role of ICs in cancer…
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See the project and researchersThe feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis
Project Overview
Surgery and radiation are standard treatments for cancer that has spread to the brain. Recent research has revealed that cancer cells with high levels of the chemical lactate are aggressive and resist radiation therapy. Dr Charles Cunningham will study whether an enhanced imaging method that can detect lactate can help…
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See the project and researchersQuantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis
Project Overview
Brain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients. It is also associated with a survival advantage compared to irradiation of…
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See the project and researchersAdvancing biology based therapies for rhabdoid brain tumours
Project Overview
Rhabdoid brain tumours are the most common brain cancers in infants. Usually these aggressive tumours are treated with intense chemotherapy and radiation therapy, which can have serious side effects. Dr Annie Huang found that these brain tumours come in 2 forms, including one that can be cured using chemotherapy alone.…