Directory of funded grants

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Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $1,647,800

  • Health Canada Contribution

    $823,900

Project Overview

In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS. One of the first discoveries about C9ORF72 was that it…

Project Complete

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A patient-derived iPSC platform of disease relevant cell models for biological studies

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $2,203,120

  • Health Canada Contribution

    $1,101,560

Project Overview

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it possible to create essentially any cell type in the body using any other as a starting point. In ALS, iPSCs provide the opportunity to take…

Project Ongoing

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Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly understood…

Project Complete

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Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Furthermore, one of the emerging areas of interest for environmental exposure is the gastrointestinal tract and how dietary exposures might…

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Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably. One of the more recent discoveries is a structure called a paraspeckle, which remains poorly understood but also has multiple components that have been identified as proteins that…

Project Complete

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