720 results found
A combined in-vivo ex-vivo approach to investigate imaging biomarkers in ALS diagnosis and aetiology
Project Overview
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death. While it is known that patients with ALS experience changes in certain brain regions visible on imaging, the relationships between these imaging markers and the underlying mechanisms of…
Project Ongoing
See the project and researchersRole of the gut microbiome-brain axis in sexual dimorphism of ALS
Project Overview
Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. However, the mechanisms underlying the sex differences in disease are poorly understood (https://www.nature.com/articles/s41582-024-00991-7). My project aims to investigate the brain-body mechanisms underlying sexual dimorphism in ALS. Specifically, I…
Project Ongoing
See the project and researchersInvestigating the role of TDP-43 in DNA Replication: Implications for ALS Pathogenesis
Project Overview
Cells are constantly under stress due to several environmental and internal factors. Accumulating stress over a period as seen in aging and neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS) puts additional pressure on the cell's coping machinery. In ALS, neurons and glial cells exhibit altered cellular processes and many proteins…
Project Ongoing
See the project and researchersInvestigating cerebellar pathology in a zebrafish C9orf72 ALS model
Project Overview
Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by degeneration of specific neurons called “Motor neurons” that control the movement of our muscles. We are particularly interested in a specific gene called C9ORF72, which is found to be mutated in most of the ALS cases.…
Project Ongoing
See the project and researchersUnravelling Molecular Mechanisms of ALS: Characterizing the in vitro and in vivo effects of biometals on the ALS-linked proteins TDP-43, SOD1, PGRN, and MFSD8
Project Overview
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, typically resulting from gene mutations that facilitate abnormal protein aggregation. Studies suggest that mutations in several proteins including TDP-43, SOD1, PGRN, and MFSD8, are linked to familial and sporadic cases of ALS (fALS/sALS). In…