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587 results found

Amyloid beta oligomers: refining the therapeutic target through photolabelling and fractionation

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Alberta

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

We know that Alzheimer's disease is caused by the clumping together of misfolded proteins in the brain, specifically two proteins called amyloid beta and tau. We know that new antibody treatments for Alzheimer’s disease target the surface of clumps of amyloid beta and remove the clumps from the brain. Unfortunately,…

Project Ongoing

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Novel digital and adaptive marker of word-finding difficulties for early detection of Alzheimer’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $200,000

  • Health Canada Contribution

    $100,000

Project Overview

Over 64% of older adults without neurocognitive disorders report forgetting the names of objects when speaking. These difficulties are commonly dismissed as typical aspects of the normal aging process. However, recent findings suggest that when these subjective word-finding challenges reach a certain level, they can serve as an indicator of…

Project Ongoing

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A “tipping point” neuron type driving Alzheimer’s Disease progression

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $200,000

  • Health Canada Contribution

    $100,000

Project Overview

Alzheimer's Disease (AD) is characterized by dysregulation of neurons involved in memory, which is believed to be caused by the production of an agent termed "amyloid beta". Amyloid beta spreads across the brain during the progression of Alzheimer's disease, with the current belief being that hyperactive neurons drive this spread…

Project Ongoing

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DBS-PPN-AD: A Pilot Clinical Trial Investigating Deep Brain Stimulation of the Pedunculopontine Nucleus for theTreatment of Alzheimer’s Disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Gamma oscillations (GO) are electrical signals detected in the brain that are essential for memory and cognition. GO are a product of the activity of a subpopulation of brain cells called parvalbumin interneurons (PVIN).Unsurprisingly, GO and PVIN are both impaired in Alzheimer’s disease (AD). Remarkably, stimulation of PVIN has restored…

Project Ongoing

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Health system implications of novel therapeutics for Alzheimer’s Disease: Supporting capacity planning with real-world evidence

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $99,951

  • Health Canada Contribution

    $49,975

Project Overview

Close to 600,000 Canadians currently live with Alzheimer’s disease and related dementias, but effective therapies are limited and focus on symptom management rather than a cure. Emerging research promises new disease-modifying drug therapies which target removal of amyloid in the brain and slow disease progression. While initial results from clinical…

Project Ongoing

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