738 results found
Elatus: Chronically Implantable Unit-Scale Microelectrode Array Neuromodulation Technology
Project Overview
Challenge: Current DRE standard of care is either DBS (Medtronic, Boston Scientific), Vagus Nerve Stimulation (VNS - Livanova) or Responsive Nerve Stimulation (RNS - NeuroPace). These devices rarely eliminate seizures, and there is little to differentiate them from one another. Typically, median seizure reduction is 50-70% which, while statistically significant,…
Project Ongoing
See the project and researchersA brain-specific approach to RNA therapeutics: developing a novel protein delivery strategy for the central nervous system
Project Overview
Challenge: Delivery of therapeutic proteins to the brain has been a longstanding barrier to CNS drug development. Protein replacement or supplementation strategies hold promise for multiple brain diseases, from enzyme-replacement for neuronopathic lysosomal disorders, to growth factor supplementation for neurodegeneration, to cytokine immunotherapy for brain cancers. However, most brain diseases…
Project Ongoing
See the project and researchersDesigning synthetic extracellular matrices to support neurodegenerative disease modeling
Project Overview
We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Human induced pluripotent stem cells (hiPSCs) have revolutionized disease modeling and drug discovery. Enhanced 2D and 3D culture models have tremendous potential to enable hiPSC development with greater cellular maturity compared to…
Project Ongoing
See the project and researchersIn-vivo CAR-T Therapy for Glioblastoma by Novel Non-Viral Gene Editing System
Project Overview
Challenge CAR-T therapies have delivered promising results for certain hematological cancers but remain largely ineffective for solid tumours with failure nodes including complex and hostile tumor microenvironments and the lack of adapted technological tools. We propose to adapt a novel gene editing system to develop an in-vivo CAR-T gene editing…
Project Ongoing
See the project and researchersMyelin loss and cognitive impairment following SARS-CoV-2 infection
Project Overview
Does SARS-CoV-2 infection increase cognitive decline via myelin loss in older individuals? Background: One in 4 persons infected with SARS-CoV-2 (the COVID-19 virus) shows cognitive decline. This decline could be related to white matter damage. The white matter is made of axons connecting neurons with each other. The integrity of…