746 results found
Decoding the Spatial Architecture of Newborn Brain Injury
Project Overview
Infants born early (preterm) are at risk for brain injury and long term neurodevelopmental challenges, including delays in walking, language development, and school-aged cognitive performance. Preterm brain injury is complex, but a major contributor to abnormal brain development is chronic exposure to low oxygen (hypoxia) due to lung immaturity. We…
Project Ongoing
See the project and researchersFrom Substitution to Participation: Recognizing Persons with Dementia as Social Citizens
Project Overview
The Canadian Charter of Rights for People with Dementia states that persons with dementia must receive the support needed to participate as fully as possible in decisions that affect them. Yet people living with dementia are often excluded from participating in decisions. This study will co-develop materials that provide direction…
Project Ongoing
See the project and researchersDisrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach
Project Overview
Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas where drugs can attach and rescue diseased cells. Once these areas are located, various drugs will be…
Project Ongoing
See the project and researchersAmyloid deposition and the glymphatic system assessed simultaneously in Alzheimer’s disease using PET/MRI
Project Overview
Poor sleep is a known risk factor for Alzheimer’s disease. This is likely due to sleep’s role in removing waste products from the brain. There is currently no way to view this waste removal process without posing a risk to the individual, but new approaches using medical imagining technologies may…
Project Ongoing
See the project and researchersQuantitative fluorescence spectroscopy of the central nervous system amylome
Project Overview
It is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key disease phenomenon. But not all amyloids cause disease, and those that do come in many different varieties. Currently, there is a lack of good ways to assess the misfolded character of…