770 results found
Evaluating DLK activity in brain samples from Huntington’s disease patients
Project Overview
"Background:Within the realm of neurodegenerative diseases, there is still a lack of effective disease-modifying treatments. Huntington’s Disease (HD) is no less immune to this issue, with only symptomatic treatment options being available for patients. In other neurodegenerative diseases, a Dual Leucine Zipper Kinase (DLK) has been identified as a novel…
Project Ongoing
See the project and researchersOptimizing nanodiscs to improve antisense oligonucleotide delivery in the treatment of Huntington disease.
Project Overview
"Antisense oligonucleotides (ASOs) are synthetic single-stranded DNA/RNA that are useful in the targeting of mRNA sequences. Their versatility allows them to enhance potency, longevity and bioavailability, making them a popular therapeutic for neurodegenerative diseases and a leading approach in clinical trials for Huntington disease (HD). However, the blood-brain barrier…
Project Ongoing
See the project and researchersInvestigating S-Nitrosylation of MCUB in Mitochondrial Calcium Dysregulation and Huntington’s Disease
Project Overview
"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and cognitive decline. Mitochondrial dysfunction is a central feature of HD pathophysiology, contributing significantly to neuronal death. Heritable mutant huntingtin protein disrupts mitochondrial dynamics, impairs oxidative phosphorylation and leads to bioenergetic deficits. A key component of…
Project Ongoing
See the project and researchersThe Mesoscopic Integrated Neuroimaging Data (MIND) Platform
Project Overview
The MIND Platform is a groundbreaking initiative that will revolutionize brain research by allowing scientists to capture and analyze unprecedented detailed images of the brain at both large and small scales. This advanced technology combines ultra-powerful MRI and lightsheet microscopy, which enables researchers to see the brain's structure and activity…
Project Ongoing
See the project and researchersBuilding Reproducible AI Frameworks for Brain Health with the Brain Health Data Challenge Platform
Project Overview
Neuroscience is on the brink of a digital revolution, where vast amounts of data from diverse individuals are supporting the creation of powerful predictive models of brain disorders. These models will help clinicians understand disease mechanisms, develop new treatments, and tailor therapies to individual patients. Artificial intelligence (AI) is central…