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552 results found

Detection of misfolded TDP-43 in CSF of ALS cases: Diagnostic potential of confirmation-specific antibodies

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Ontario

  • Start Date

    2018

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms. One of the hallmarks of ALS for 97 per cent of cases is the accumulation of misfolded TDP-43…

Project Ongoing

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Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $30,692

  • Health Canada Contribution

    $15,346

Project Overview

A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis. He then tested them with a battery of potential treatments to see if they could find one that would have a positive effect on motor neuron…

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Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract. Other specialized neurons inhibit these signals, allowing muscles to relax. When this inhibitory process does not occur, motor neurons become overexcited, a hallmark feature of ALS before symptoms appear, particularly in the upper…

Project Ongoing

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Characterizing Enterovirus Disruption of Autophagy as a Disease Mechanism for ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    British Columbia

  • Start Date

    2018

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes. However, some enteroviruses are more serious, like enterovirus D68 that can cause severe respiratory illnesses or the poliovirus that causes…

Project Complete

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Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Ontario

  • Start Date

    2018

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly. In the majority of ALS cases, a protein known as TDP-43 becomes misfolded and accumulates in motor neurons, causing toxicity. The accumulation of misfolded TDP-43 also occurs in…

Project Complete

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