746 results found
The development of an online peer navigation intervention for youth with neurodevelopmental disabilities
Project Overview
Background: Transition from the pediatric to adult health care system is a multi-faceted process that should include medical and psychosocial considerations. Despite the importance of ensuring successful transition and independence in the community, and the significant detrimental health outcomes related to poor transition, there has been limited implementation of effective…
Project Ongoing
See the project and researchersEnhancing Supports for Autistic Post-Secondary Students at the University of Calgary
Project Overview
Autistic individuals are disproportionately under-represented in post-secondary institutions, with only 35% of students with autism pursuing post-secondary education. Of those individuals with autism who do enter post-secondary environments, only 39% are likely to graduate. A lack of available autism specific supports has been suggested to interfere with successful post-secondary education.…
Project Ongoing
See the project and researchersNeuronal reprogramming as a novel therapeutic strategy to treat Amyotrophic lateral sclerosis
Project Overview
The demonstration that mature somatic cells can be converted to new, heterologous cell types, now termed “cellular reprogramming”, led to the 2012 Nobel Prize in Physiology or Medicine, and sparked an explosion of studies investigating the therapeutic potential of such an approach. Direct neuronal reprogramming refers to the conversion of…
Project Ongoing
See the project and researchersAberrant tRNA function exacerbates TDP-43 misfolding and toxicity in cellular models of ALS
Project Overview
Aberrant tRNA processing and function has the capacity to exacerbate misfolding of ALS-associated proteins and the ensuing toxicity. tRNAs mainly function to recruit amino acids to ribosomes, allowing faithful translation of mRNA molecules. Metabolites of processed tRNAs also function in cellular stress responses, such as inducing stress granule formation. The…
Project Ongoing
See the project and researchersElucidating the role of stress granules dynamics in the pathogenesis of ALS
Project Overview
The lifetime risk of developing amyotrophic lateral sclerosis (ALS) is approximately 1 in 350 for men and 1 in 440 for women, making it the most common adult-onset motor neuron disease. There is no cure and poor prognosis for this devastating neurodegenerative disease, resulting in increased mortality and morbidity. With…