Directory of funded grants

The impact of motherhood and APOE genotype on the aging brain

Project Overview

Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines in memory and other cognitive functions. The reasons for these discrepancies, however, have not been identified. Recent studies have found that pregnancy and motherhood promote significant changes in the aging…

Microfluidic Screening Technology for the Discovery of Function-Modifying Antibodies Against Membrane Protein Targets

Project Overview

Antibody (Ab)-based therapeutics are the fastest growing class of drugs, with approximately 60 approved molecules that represent a market of over $80B. To date, the growth of this market has been due to new therapeutics against targets that can be prepared as soluble antigens. Attention is now turning to more…

Mouse brain imaging for neurodevelopmental disorders

Project Overview

The project provides state of the art mouse brain imaging to researchers in Canada working on models of neurodevelopmental disorders. The use of mouse models enables scientists to probe the function of the multiple genes implicated in neurodevelopmental disorders. Our ability to characterize the phenotype of each of these mouse…

Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivo

Project Overview

Recording the electrical impulses of neurons with optical methods in the brain will be enormously beneficial for understanding how the healthy brain functions, as well as how diseases of the brain impact its normal function. In this project, we will develop methods to record electrical activity from many individual neurons…

Capacity Building for Evidenced Based Mental Health Service Providers