Directory of funded grants

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519 results found

Testing therapeutic approaches to improve cognitive dysfunction in a primate model of Alzheimer’s Disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $857,062

  • Health Canada Contribution

    $428,531

Project Overview

Alzheimer’s Disease (AD) is a severe dementia that is likely a result of years of buildup in the brain of molecules called amyloid-beta oligomers (AβOs). The pursuit of new disease-modifying therapeutics for AD that change the natural progression of AD early in its course is under intense investigation. A major…

Project Ongoing

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Novel approaches to understand the role of cAMP and co-signaling cascades in synaptic plasticity and brain disorders

  • Program Type

    Team grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $1,850,000

  • Health Canada Contribution

    $925,000

Project Overview

Synaptic plasticity is the process where the strength of connections between nerve cells is altered by experience. It is widely believed that synaptic plasticity is used to store information in the brain and is important for learning and memory and other major cognitive processes. The most widely studied form of…

Project Complete

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Cognitive Outcomes and Response/Remission Efficacy of Convulsive Therapies in Treatment Resistant Depression: The CORRECT-TRD Trial

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $1,387,424

  • Health Canada Contribution

    $693,712

Project Overview

Magnetic Seizure Therapy (MST) is a novel form of treatment that uses high intensity magnetic field pulses to stimulate the brain and induce a seizure as a therapeutic intervention for patients with depression resistant to antidepressant medication, known as Treatment Resistant Depression (TRD). Preliminary research has shown that MST is…

Project Ongoing

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The Aging Brain: Circadian, Transcriptomic, and Epigenomic Dimensions

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $1,231,293

  • Health Canada Contribution

    $615,646

Project Overview

One of the most important questions of biomedical research is “why do we ail as we age?”. This may be in part due to a breakdown of the body’s circadian rhythm - the physiological process that tunes up or down various bodily functions during the 24 hr cycle. Another aspect…

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Reshaping Mitochondrial Efficiency and Integrity to Treat Parkinson’s Disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

Parkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. This movement disorder is thought to be due to the loss of a specific population of nerve cells, the dopamine (DA)-containing neurons located in the substantia nigra pars compacta (SNc). The question as to why this…

Project Complete

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