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551 results found

Pathogenic mechanisms of C9ORF72 repeat expansion in ALS and development of therapeutics

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $215,000

  • Health Canada Contribution

    $107,500

Project Overview

Dr. Patten started his research career as a PhD student at the University of Alberta under the supervision of Dr. Declan Ali in 2004. There he trained in electrophysiology, cell biology and imaging using zebrafish as a model to study neurodevelopment. After publishing several manuscripts on his discoveries and receiving…

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Discovery of transcriptomic biomarkers and epigenetic therapeutic targets for c9ALS and sALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Other

  • Start Date

    2016

  • Total Grant Amount

    $96,250

  • Health Canada Contribution

    $48,125

Project Overview

Dr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. During this time, Dr. Belzil pursued a better understanding of the genetics behind familial/hereditary ALS and…

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Characterization of MATR3 Mutations Associated with ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $315,000

  • Health Canada Contribution

    $157,500

Project Overview

For this project, Dr. Park will examine how abnormalities in RNA binding proteins (RBPs) – in particular, one called Matrin 3 (MATR3) – can lead to ALS. MATR3 was discovered to be a genetic cause of ALS in 2014 and has yet to be studied in any detail. By creating…

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Mechanisms of glutamatergic neuronal dysfunction in genetic models of ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $315,000

  • Health Canada Contribution

    $157,500

Project Overview

This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction.  Recent evidence from a number of labs has indicated that errors in neurotransmission of signals might be one of the first pathological effects in…

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Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $195,000

  • Health Canada Contribution

    $97,500

Project Overview

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the…

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