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Stroke is a life threatening emergency caused by blocked arteries that affects 45,000 Canadians a year. Each hour a stroke is left untreated means brain cells are dying. Project Overview Stroke is a life threatening emergency caused by blocked arteries that affects 45,000 Canadians a year. Each...

Therapeutic breakthroughs in Huntington Disease (HD), Alzheimer’s Disease (AD), Parkinson Disease (PD), and other neurodegenerative disorders have been accelerated by access to generously donated human samples. The HD Biobank at the University of British Columbia focuses on neurodegenerative...

The abnormal accumulation of misfolded proteins and aggregates is the hallmark of multiple forms of ALS and other neurodegenerative diseases. Project Overview The abnormal accumulation of misfolded proteins and aggregates is the hallmark of multiple forms of ALS and other neurodegenerative...

Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines in memory and other cognitive functions. Project Overview Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines...

Thanks to advances in cancer treatments, more than 80% of children treated for brain tumors now survive at least five years after their diagnosis. Project Overview Thanks to advances in cancer treatments, more than 80% of children treated for brain tumors now survive at least five years after their...

Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain injuries as well as with normal aging despite any clear pathological condition. Project Overview Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain...

The Huntington disease (HD) mutation produces a pathogenic mutant HTT (mHTT) protein with an elongated polyglutamine tract. Presence of mHTT disrupts diverse cellular pathways, leading to adverse molecular phenotypes including inflammation, impaired synaptic transmission, and eventually...

Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD. Project Overview Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not...

Autism spectrum disorder (ASD) is characterized by difficulties with communication, social deficits as well as repetitive behaviors and interests. Project Overview Autism spectrum disorder (ASD) is characterized by difficulties with communication, social deficits as well as repetitive behaviors and...

Thanks to the late Dr. William Feindel’s vision, who in the 1970’s believed that brain imaging was the “future for neurology and neurosurgery”, and to a generous donation, the Montreal Neurological Institute (The Neuro) inaugurated the McConnell Brain Imaging Center (BIC) in 1984. Project...