Before dementia occurs, the brain has issues getting enough energy and blood flow. This causes subjective cognitive decline (SCD) and is an early warning sign for dementia. Exercise and ketone supplements may help correct these problems. Stronger muscles can boost blood flow and energy delivery to the brain, while ketone supplements provide an additional fuel source to support brain function.
This study will test if exercise training and daily ketone drinks can improve brain and muscle health in adults with SCD aged 60 to 80 years. Participants will do strength and cardio exercise 3x/week and take either a ketone or placebo drink 3x/day for 12 weeks. We will use specialized brain scans (MRI) to measure brain function and brain blood flow. We will also measure cognitive abilities, muscle function, and take muscle samples. This study will help discover new ways that lifestyle changes can protect against dementia in aging.
