We need new ways to treat Alzheimer’s Disease (AD). People with AD are keen to try non-drug therapies but none are approved for treating AD. Remote ischemic conditioning (RIC) is a non-drug therapy that involves inflating and deflating blood pressure cuffs repeatedly in the arm or leg. In mice, RIC seems to change processes involved in AD and improve cognitive decline. It has not been tested in patients with AD. We will conduct a clinical trial, called TRIC-AD, to answer two main questions: 1. Do patients with AD who receive RIC show changes in blood markers that are relevant to AD, compared to sham therapy? 2. Are patients with AD able to tolerate treatment with RIC? Can they adhere to this therapy over one year?
