Alzheimer’s disease is linked to the build-up of harmful proteins in the brain and damage to brain blood vessels. In many people, especially in later life, this build-up happens because the brain cannot clear these proteins effectively. Our research focuses on understanding how aging damages the blood vessels in the brain and reduces this natural cleaning process. We have discovered that certain age-related protein changes may block the removal of these harmful substances. This project aims to develop a new antibody-based treatment to repair blood vessel function and restore the brain’s ability to clear the damaged proteins. By improving this natural clearance system, we hope to prevent or slow down Alzheimer’s disease and vascular dementia.
