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6 résultats trouvés

The University of British Columbia Genes, Cells and Circuits (UBC-GC2) platform for next-generation multiscale brain research

There is an urgent need for research that deepens our understanding of human brain function and uses this knowledge to accelerate therapeutic breakthroughs related to brain dysfunction.


TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Multiple
Province
Colombie-Britannique
DATE DE DÉBUT
2025

Cytosolic DNA sensing in ALS-related neuroinflammation

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2021

Mechanisms of in vitro synaptic transmission of mis-folded human SOD1

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to another.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2017

A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65.


TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurodégénérescence
Concours
CQDM - Brain Canada - Pleins feux sur le cerveau
Province
Québec
DATE DE DÉBUT
2016

Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

A treatment or prevention of Alzheimer’s disease is a top priority for medical science.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2015

Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons).


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2014