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A National biobank and database for patients with traumatic brain injury

Principal Investigator:
  • Jamie Hutchison, The Hospital For Sick Children
Team Members:
  • Andrew Baker, St. Michael's Hospital
  • Karen Barlow, Alberta Children's Hospital Research Institute
  • David Clarke, Capital District Health Authority
  • Michael Esser, Alberta Children's Hospital Research Institute
  • Robin Green, Toronto Rehabilitation Institute
  • Anne-Marie Guerguerian, The Hospital For Sick Children
  • Jacques Lacroix, Sainte-Justine University Hospital Centre
  • Alain Ptito, McGill University
  • Keith Walley, James Hogg Research Institute
  • Grant Iverson, University of British Columbia
  • Anthony G. Phillips, University of British Columbia
  • Elizabeth Theriault, University of British Columbia
  • Cheryl Wellington, University of British Columbia
  • Suzanne Vercauteren, BC Children’s Hospital (BCCH)
  • Ash Singhal, BC Children's Hospital and BC Women's Hospital & Health Centre
  • Peter Skippen, BC Children’s Hospital (BCCH)
  • Elaine Gilfoyle, Alberta Children's Hospital Research Institute
  • Ari Joffe, University of Alberta
  • David Zygun, University of Alberta
  • Clare Gallagher, University of Calgary
  • Thomas Sawyer, University of Calgary
  • Sam Weiss, University of Calgary
  • Brent Winston, University of Calgary
  • Greg Hansen, Manitoba Children’s Hospital
  • Murray Kesselman, Manitoba Children’s Hospital
  • Peter Dirks, The Hospital For Sick Children
  • Cynthia Hawkins, The Hospital For Sick Children
  • Angela Colantonio, University of Toronto
  • Karen Choong, McMaster University
  • Alison Fox-Robichaud, McMaster University
  • Patricia Liaw, McMaster University
  • Jane Batt, St. Michaels Hospital
  • Shiva Amiri, Ontario Brain Institute (OBI)
  • Donald Stuss, Ontario Brain Institute (OBI)
  • Douglas Fraser, Children’s Health Research Institute
  • Corinne Kagan, Ontario Neurotrauma Foundation (ONF)
  • Michelle Keightley, Holland Bloorview Kids Rehabilitation Hospital
  • Martin Osmond, Children’s Hospital of Eastern Ontario (CHEO)
  • Roger Zemek, Children’s Hospital of Eastern Ontario (CHEO)
  • Charles H Tator, Krembil Research Institute
  • Catherine Farrell, Sainte-Justine University Hospital Centre
  • Ronald Gottesman, Montreal Children’s Hospital (MCH)
  • Paul Hébert, Centre hospitalier de l'Université de Montréal (CHUM)
  • Bonnie Swaine, Centre hospitalier de l'Université de Montréal (CHUM)
  • Alexis Turgeon, Université Laval
  • Lynne Fenerty, Dalhousie University
  • Providence Health Care Society
  • Child. & Women's Health Centre of BC
  • University of Calgary
  • Hospital for Sick Children
  • Ontario Neurotrauma Foundation
  • CHU Ste Justine Foundation
  • Nova Scotia Health Authority
  • University of British Columbia
  • Genome BC
  • Djavad Mowafaghian Centre for Brain Health

Project Overview

Traumatic brain injury is the leading cause of death and disability in children and young adults in Canada. Despite huge developments in basic neuroscience, no new therapies or diagnostic tests have been introduced in clinical care over the past 30 years. In the acute setting, neither clinicians nor researchers are able to predict long term outcome, which makes it difficult to tailor care, rehabilitation interventions or support services. Canadian scientists have previously been working separately, developing biobanks for studies of molecular biomarkers and studying mechanisms in laboratory models of TBI. The discovery and validation of molecular biomarker, in human, holds promise for diagnosis, outcome prediction and for monitoring response to new drugs or molecular therapies, rehabilitation and targeted psychotherapy. To study these promising biomarkers, an integrated translational biology approach is needed. The funding for this project will help link current and planned biobanks for traumatic brain injury, to a central state-of-the art neuroscience database at the Ontario Brain Institute. It will permit more rapid pilot studies with emerging laboratory technologies and novel approaches and will enable our scientists to be more competitive when applying for peer-reviewed funding. It will also position Canadian scientists to lead ground-breaking neuroscience research as part of the International Initiative for Traumatic Brain Injury Research. This Platform Support Grant provides an essential step to help Canadian scientists lead a paradigm shift in the care of these patients with traumatic brain injury.