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Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

Project Overview

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm. The mislocated TDP-43 may be toxic to motor neurons because it aggregates in the cytoplasm, or because it is no longer performing its normal function in the nucleus.

Scientists have also discovered that mutations in another protein, called hnRNP A1, can cause ALS. In 2018, Dr. Christine Vande Velde discovered that when TDP-43 moves out of the cell nucleus, a new version of hnRNP A1 forms, called hnRNP A1B. Her preliminary work has shown that this new protein may be even more toxic and appears to have a greater ability to form potentially toxic clumps.

With this grant, Myriam Gagné will aim to understand how hnRNP A1B is involved in ALS disease processes by performing cell and mice experiments. She will also validate her findings using ALS tissue samples generously donated by people who had ALS.

Gagné hopes that new insights about the role of hbnRNP A1B in ALS may reveal a better understanding of disease processes and potential targets for new therapies and biomarkers.

Source: https://www.als.ca/research/als-canada-research-program/projects-funded/projects-funded-2019/

 

Principal Investigator

Myriam Gagné , Centre Hospitalier de l’Université de Montréal

Partners and Donors

ALS Society of Canada

La Fondation Vincent Bourque

Project Complete

Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2019

  • Province

    Québec

  • Start Date

    2019

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

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The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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  • About
    • What We Do
    • EDI Action Plan
    • Leadership
    • Team
    • Annual Report
    • Publications
    • Careers
  • Brain Conditions
    • One Brain
    • ALS
    • Autism (ASD)
    • Brain Cancer
    • Brain Injury
    • Dementia
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • More
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
    • Research Impact Stories
    • Equity, Diversity and Inclusion
    • Brain Health in Indigenous Communities
    • Women’s Brain Health
    • Mind Over Matter
  • How You Can Help
    • Ways to Give
    • Start a Fundraiser
    • Workplace Giving
    • The Great Minds
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