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Funded Grants

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Brain channelopathies: target validation and novel therapeutic strategies

Project Overview

The entry of calcium ions into cells is mediated by a class of protein (called calcium  channels) that responds to electrical signals by opening of a calcium-selective pore.  Calcium channels are involved in a large number of physiological processes including  muscle contraction, hormone secretion and nerve cell communication in the nervous system. These physiological processes each require optimal amounts of calcium and alteration of the precise amounts can be highly detrimental. In this proposal we will study brain disorders that result from small genetic alterations in calcium channel genes expressed in the nervous system. One of these alterations causes a severe form of migraine headache, another underlies a common type of epilepsy and a third results in a multi-system disorder that includes autism. Further, we will examine a particular calcium channel genetic change that is found in population studies to be strongly correlated with schizophrenia and bipolar disorders. While drugs have been developed to regulate a certain type of calcium channel in the  cardiovascular system and are widely used to treat hypertension and heart failure, as yet there have not been specific treatments developed to target calcium channels involved in diseases of the nervous system. To both address this important therapeutic issue and to help determine how the different genetic alterations in calcium channel genes affect brain functioning, we will test a number of newly developed technical strategies aimed at regulating calcium channel activity. The research team has expertise across a broad area of the neurosciences and together with utilizing animal models of the calcium channel disorders, we aim to provide new insights into how particular genetic alterations affect calcium channel properties resulting in the disruption of normal brain functions and causing serious diseases of the nervous system.

Principal Investigator

Terry Snutch , University of British Columbia

Team Members

Brian MacVicar, University of British Columbia

Yu Tian Wang, University of British Columbia

Pieter Cullis, University of British Columbia

John Howland, University of Saskatchewan

Partners and Donors

Genome BC

Michael Smith Foundation For Health Research

University of Saskatchewan

University of British Columbia

Project Ongoing

Brain channelopathies: target validation and novel therapeutic strategies

  • Program Type

    Team grants

  • Area of research

    Neurotechnology

  • Disease Area

    Other

  • Competition

    2012 MIRI Team Grants

  • Province

    British Columbia

  • Start Date

    2014

  • Total Grant Amount

    $1,425,000

  • Health Canada Contribution

    $712,500

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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Registration number: 89105 2094 RR0001

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