Project Overview

Optogenetics is a relatively new science subdomain that is revolutionizing brain research with great promises for therapeutics. Oxford dictionary defines it as a technique in neuroscience in which genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals.

The proposal is to take advantage of world leaders from universities across the nation to position Canada at the forefront of the optogenetics revolution. The proposed Canadian Optogenetics and Vectorology Foundry aims to accelerate the development of new light responsive genes and proteins through the implementation of a design-build-test loop for biological engineering. New optogenetics tools will be designed at the DNA level and built into viruses which serve as vehicles for delivery of the tool into cells for testing and validation. Vectorology, the building of modified non-toxic viruses, allows for the transfer of a gene of interest into organs of live animals to induce production of the protein corresponding to that gene in a cell-type specific manner. The proposed development loop will also accelerate the path to gene therapies and the use of light to treat brain disorders. New tools will be tested in various models, from lower organisms, to mice, to non-human primates and human cells. This is a critical continuum to support the development of new diagnostics and drug development/validation tools, as well as clinical applications. All of the results obtained from the testing of various optogenetics tools will be shared with the scientific community and easily accessible through an open-science platform.

Principal Investigator

Yves De Koninck , Université Laval

Team Members

Marie-Eve Paquet, Université Laval

De Koninck, Paul, Université Laval

Robert Campbell, University of Alberta

Keith Murai, Research Institute of the McGill University Health Centre

Edward Ruthazer, McGill University

Stuart Trenholm, McGill University

Reza Sharif-Naeini, McGill University

Thomas Durcan, Montreal Neurological Institute and Hospital, McGill University

Tomoko Ohyama, McGill University

Edward Fon, McGill University

Jean-Claude Béïque, University of Ottawa

Stephanie Borgland, Hotchkiss Brain Institute, University of Calgary

Lynn Raymond, University of British Columbia

Partners and Donors

University of British Columbia / Vancouver Coastal Health Authority

University of Calgary

University of Ottawa

McGill University

McGill University Health Centre - Research Institute

CIUSSS-CN (CERVO Brain Research Centre)