Skip to content
Project Directory
  • Français
Donate Now
  • Français
  • About
    • What We Do
    • Leadership
    • Team
    • Publications
    • Careers
  • Diseases/Disorders
    • One Brain
    • ALS
    • Alzheimer’s
    • Autism
    • Brain Cancer
    • Brain Injury
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • Other
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
  • Ways To Give
    • Your Impact
    • How You Can Help
    • Events

Funded Grants

Back to results

Co-clinical trials of autism in mice and humans

Project Overview

Autism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. It is very heterogeneous, with over 250 genes implicated, but is highly heritable. The current therapeutic approach is frequently ineffective partly because often a single treatment is given to a heterogeneous patient population. This project will address the lack of individualized treatment in autism through a parallel co-clinical trial of promising autism treatments in mice and humans. Treatments will be oxytocin, a drug associated with increased social behaviours, and Tideglusib, a drug that acts on a protein downstream of the most common single gene cause of an autism-related disorder. Both humans (phase II clinical trial) and mice will be treated with promising drugs, and analyzed and compared on behavioural, genomic, and advanced, high-resolution imaging measures. Ms. Lindenmaier hypothesizes that this will allow the identification of both genetic and phenotypic information that can be used to stratify individuals with autism into responders and non-responders for specific treatment options. Ultimately, she hopes to make the first steps towards a personalized medicine approach in autism in which there are defined effective therapies for subpopulations of the disorder.

Principal Investigator

Zsuzsa Lindenmaier , University of Toronto

Partners and Donors

Hospital for Sick Children

Project Ongoing

Co-clinical trials of autism in mice and humans

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $70,000

  • Health Canada Contribution

    $35,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Playing with Marbles Podcast

Join us and take a journey to the real last great frontier – the brain.

Listen

Subscribe to Brain News

Receive our monthly electronic newsletter with updates on funded projects, upcoming events and breakthroughs in brain research.

Sign up

© 2023 Brain Canada Foundation

Registration number: 89105 2094 RR0001

  • Terms and Conditions
  • Privacy Policy

Design by Field Trip & Co