Cortical GABAergic interneurons migration impairment in genetic epileptic encephalopathies
Project Overview
Dr. Eid will test the hypothesis that the Trio gene is a central regulator of the development and maturation of cortical interneurons (INs) and that its loss underlies some genetic forms of epileptic encephalopathies (EE) by disrupting cortical network development and function. Her research combines state-of-the art approaches in genetics and imaging to expand the understanding of the roles of Trio in brain development. It will specifically reveal its requirement in IN development, while clarifying the potential implication of deficits in IN migration and development in the pathophysiology of some genetic forms of severe neurodevelopmental disorders, including intellectual disability (ID) and EE. Furthermore, by identifying Canadian children with potential “interneuronopathies”, this project will help select those that might benefit from promising cell-based or cell-selective therapies. Such personalized medicine approaches may eventually transform the care of children with severe neurodevelopmental disorders.
Principal Investigator
Lara Eid , CHU-Saint Justine
Partners and Donors
CHU Ste-Justine