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Funded Grants

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Interleukin-1 blockade along with hypothermia to prevent cerebral palsy arising from refractory neonatal asphyxia

Project Overview

Neonatal asphyxia and subsequent cerebral palsy (CP) is a severe pathology resulting from lack of oxygen and/or infection-inflammation. This disease still leads to mortality or severe brain injuries and long-term disabilities. Therapeutic hypothermia (decreased body temperature to 33-34°C during 3 days) is the only treatment available for these newborns. Despite hypothermia treatment, more than 50% of these newborns present neurological sequelae. This highlights the need to look for new neuroprotective treatments. This project tests the hypothesis of the efficacy of a targeted anti-inflammatory compound (namely, interleukin-1 receptor antagonist, blocking the action of a key natural inflammatory molecule called interleukin-1 (IL-1)) combined with hypothermia to prevent neonatal cerebral injuries resulting from lack of oxygen and/or infection around birth. The results will provide a better understanding about harmful interactions between the immune and nervous systems. This project will pave the way towards new therapeutic avenues to prevent CP.

Principal Investigator

Mathilde Chevin , McGill University Health Centre

Partners and Donors

McGill University

Project Ongoing

Interleukin-1 blockade along with hypothermia to prevent cerebral palsy arising from refractory neonatal asphyxia

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Other

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $70,000

  • Health Canada Contribution

    $35,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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Registration number: 89105 2094 RR0001

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