Project Overview

Converging research efforts have recently identified five genes that are associated with familial Parkinson’s Disease (PD), a condition associated with severe motor dysfunction and loss of dopamine-producing cells in the brain. These genes include α-synuclein, Parkin, DJ-1, Pink1, LRRK2. It is striking that all of them have been linked directly or indirectly with the function of mitochondria, small ubiquitous intracellular organelles found in all cells. A research group, led by Dr. Louis-Eric Trudeau from the Université de Montréal undertook collaborative projects to systematically examine PD genes and their control of mitochondrial function and neuronal physiology and survival.

Principal Investigator

Louis-Eric Trudeau , Université de Montréal

Team Members

Edward Fon, McGill University

David Park, University of Ottawa

Heidi McBride, McGill University

Michael Schlossmacher, University of Ottawa

Yong Rao, Centre for Research in Neuroscience