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Funded Grants

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Neuroinflammatory susceptibility to vascular disease as a dementia driver

Project Overview

Recent studies have shown that damage to the small blood vessels in the brain (cerebrovascular disease) may increase the risk for Alzheimer’s. However, not everyone with small vessel damage develops memory problems, suggesting there are other factors that mediate this risk. Since brain inflammation is a key characteristic of both cerebrovascular disease and Alzheimer’s, it could be a common link between the two diseases. Walter Swardfager, Ph.D., and colleagues hypothesize that variation in genes related to inflammation may affect how the brain responds to blood vessel damage. Dr. Swardfager will study the relationship between brain blood vessel damage and Alzheimer’s disease in 644 individuals who are part of the ongoing Sunnybrook Dementia Study. About half of the participants have Alzheimer’s disease and about a third of them also have cerebrovascular disease. The researchers will use brain imaging to measure blood vessel damage and brain function. They will also do a genome-wide interaction study (GWIS) for each participant to determine which genetic variations relate to changes in brain structure and memory decline.

https://www.alz.org/research/for_researchers/grants/funded-studies-details?FundedStudyID=1058

 

Principal Investigator

Walter Swardfager , Sunnybrooke Research Institute

Partners and Donors

Alzheimer's Association

Project Ongoing

Neuroinflammatory susceptibility to vascular disease as a dementia driver

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association Research Grant

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $194,981

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+1 (514) 989-2989 info@braincanada.ca

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