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Funded Grants

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Novel approaches to central nervous system white matter repair

Project Overview

Many nerve cells in the body are covered with a protective sheath known as myelin, which allows fast conduction of nerve impulses, and which is produced by two different types of cells called oligodendrocytes and Schwann cells. Demyelination occurs when this protective covering is destroyed, resulting in impaired nerve function. While demyelination is most closely associated with Multiple Sclerosis, it is also implicated in other neurological and psychiatric conditions such as schizophrenia and spinal cord injuries. The term white matter is used to describe areas of the brain and spinal cord that contain many myelinated nerve fibres, and it is the white matter that is responsible for information transmission in the body.

The goal of this project was to attempt to repair these damaged, demyelinated nerve cells using a stem cell-based approach. In this team’s research, oligodendrocyte and Schwann cell stem cells was transplanted into an injured spinal cord in order to see if remyelination and subsequent improved nerve function will result.

Principal Investigator

Freda Miller , University of Toronto

Team Members

David Kaplan, University of Toronto

Wolfram Tetzlaff, University of British Columbia

Samuel Weiss, University of Calgary

Project Complete

Novel approaches to central nervous system white matter repair

  • Program Type

    Team grants

  • Competition

    Brain Repair Program

  • Province

    Ontario

  • Start Date

    2004

  • Total Grant Amount

    $1,500,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

+1 (514) 989-2989 info@braincanada.ca

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