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Funded Grants

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Parent-therapist partnership to provide early, intensive exercise to enhance walking outcomes in children with perinatal stroke

Project Overview

Perinatal (around birth) stroke is devastating, because the effects are life-long. Current treatments to improve walking are limited, and largely passive, such as stretching, bracing, botulinum toxin injections and surgery. Recent work in animals indicates that intensive active therapy is effective in the young, when nerve pathways for movement are maturing, but not when the animals are older. Dr. Yang’s group has applied these principles in a laboratory-based study in young children with perinatal stroke, using play-based, intensive activity, 4 days/week over 12 weeks. The results have been very promising, showing that intensive therapy in young children is feasible and results in better mobility than current care.

Here, the team designed a study with parents, clinicians, managers, and researchers, to extend this treatment to the real-world. The treatment will be delivered by partnering parent(s) with frontline physical therapists. This partnership was not only considered more feasible by their parent collaborators, but importantly, more empowering. Three centres – Edmonton, Calgary and Ottawa – will be involved. All children will be followed until they turn 4 years old to determine if long-term outcomes are better than published outcomes for similar children. The quality of life for the child and their family will be measured, as will the cost-effectiveness of the treatment. If successful, the treatment will be translated broadly to other therapists and parents. The hope is to reverse the current passive approaches to an intensive, active approach, which could lead to benefits for the child and their family well beyond the study period.

Principal Investigator

Jaynie Yang , University of Alberta

Team Members

John Andersen, University of Alberta

Adam Kirton, Alberta Children’s Hospital Research Institute

Man-Joe Watt, University of Alberta

Heidi Sveistrup, University of Ottawa

Jennifer Zwicker, University of Calgary

Anna McCormick, Children’s Hospital of Eastern Ontario (CHEO) Research Institute

Elizabeth Condliffe, University of Calgary

Partners and Donors

Women and Children's Health Research Institute

University of Alberta

Project Ongoing

Parent-therapist partnership to provide early, intensive exercise to enhance walking outcomes in children with perinatal stroke

  • Program Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Improving Health Outcomes and Quality of Life

  • Province

    Alberta

  • Start Date

    2018

  • Total Grant Amount

    $537,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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