It is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key disease phenomenon. But not all amyloids cause disease, and those that do come in many different varieties. Currently, there is a lack of good ways to assess the misfolded character of brain proteins. The goal of this study is to devise new methods to more accurately assess the nature and extent of amyloid accumulation in the brain. This study’s approach will yield new methods for detecting a variety of amyloids in the brain. It will also allow detection of very subtle pathology (unlike the more obvious, and well-known, plaques). Eventually, this study’s methods could be adapted to blood or other body fluids for early detection and response to treatment.