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DIgital markers of Social Cognition for diagnosis & pRognosis in Neurodegeneration (DISCeRN)

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    EU Joint Programme – Neurodegenerative Disease Research (JPND)

  • Province

    Québec

  • Start Date

    2026

  • Total Grant Amount

    $333,000

Project Overview

Impairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND). Current clinical approaches related to SC fail to capture the dynamic nature of social…

Project Ongoing

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New function for DEPTOR tyrosine 289 phosphorylation in glioma metabolism 

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Québec

  • Start Date

    2025

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

Deregulation of brain cell metabolism is commonly observed in low-grade brain cancers. Although the precise molecular mechanisms remain ill define, it is now clear that brain cancer cell often harbor altered metabolic function that promotes cell proliferation and survival. Recent evidence shows that metabolic imbalance can be an early event…

Project Ongoing

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Investigating the role of L-glucose as a therapy and [18F]fluoro-deoxy-L-glucose as a diagnostic for glioblastoma

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Ontario

  • Start Date

    2025

  • Total Grant Amount

    $134,930

  • Health Canada Contribution

    $67,465

Project Overview

Using the mirror image of body’s main sugar glucose (so-called L-glucose), we plan to hijack the sugar addiction of glioblastoma (GBM) as a therapeutic target. To assessthe behavior of the unnatural form of glucose in living brain tumors, we have created a radioactively tagged L-glucose that wasfound to selective enter…

Project Ongoing

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Exploring New Therapeutic Approaches for Medulloblastoma  

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Doctoral Research Awards

  • Province

    Québec

  • Total Grant Amount

    $70,000

Project Overview

Medulloblastoma (MB) is a brain cancer that affects children. Current treatment for MB leaves patients with debilitating brain issues. We found that aggressive MB have low activity of a process called nonsense mediated decay (NMD). Therefore, by increasing NMD activity, we might treat MB. To test this, I generated MB…

Project Ongoing

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Mapping and targeting cellular heterogeneity in sonic hedgehog medulloblastoma 

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Doctoral Research Awards

  • Province

    Ontario

  • Total Grant Amount

    $70,000

Project Overview

Medulloblastoma isthe most common brain cancer in children. The current treatment for it includestoxic chemotherapy drugs which leadsto severe long-term side effectslike cognitive impairment. Still, the treatment failsfor many patients because some of the cells within the tumor are insensitive to the chemotherapy. There is a clear lack of research…

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