721 results found
Cortical GABAergic interneurons migration impairment in genetic epileptic encephalopathies
Project Overview
Dr. Eid will test the hypothesis that the Trio gene is a central regulator of the development and maturation of cortical interneurons (INs) and that its loss underlies some genetic forms of epileptic encephalopathies (EE) by disrupting cortical network development and function. Her research combines state-of-the art approaches in genetics…
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See the project and researchersIn utero exposure to glucocorticoids in humans and an animal model: Epigenetic and transcriptional signatures
Project Overview
Dr. Sasaki research aims to (1) determine the mechanisms by which maternal synthetic glucocorticoids (sGC) modifies gene networks in a preclinical guinea pig model and (2) determine the mechanism by which a single maternal treatment of sGC modifies gene networks in human cord blood at term deliveries. To date, there…
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See the project and researchersEffects of Sex Hormone Therapy on Brain Development in Adolescents Experiencing Gender Dysphoria: A Magnetic Resonance Imaging Study
Project Overview
Adolescence is a time of rapid brain maturation that is partly influenced by sex hormones. In this project, magnetic resonance imaging will be used to assess the influence of sex hormones on brain structure and function. Malvina Skorska will examine how the brain structure and function of adolescents who experience…
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See the project and researchersBrain-Computer Interface Integrated Augmentative and Alternative Communication
Project Overview
The primary objective of Ms. Shea's research is to investigate an optimized integration of event related potentials (ERPs) as a means to augment assistive communication devices. Words, chosen through contextual constraints and rapidly presented to individuals offer superior communication efficiency over independent sequential letter selection. During the rapid presentation of…
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See the project and researchersCRISPR/Cas9-Mediated Gene Therapy to Correct Aniridia in a Mouse Model
Project Overview
Ms. Zeinab Mohanna's research will test the hypothesis that CRISPR/Cas9-mediated genome editing can increase the expression of PAX6 protein, improve the function of the neural and other tissues of the eye, and ultimately rescue the mutant phenotype in the mouse model of aniridia. Rare genetic diseases create a burden on…