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676 results found

Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably. One of the more recent discoveries is a structure called a paraspeckle, which remains poorly understood but also has multiple components that have been identified as proteins that…

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Defining conserved functions of RNA binding proteins in stress-granule biogenesis

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Since the discovery of TDP-43 in 2006 as a substance that plays a major role in ALS, the hypothesis that abnormal regulation…

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Impaired Neuromuscular Junction Connectivity in Amyotrophic Lateral Sclerosis

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    British Columbia

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Many scientists believe that one of the earliest abnormalities in ALS is dysfunction at the place where motor neurons connect to muscle, known as the neuromuscular junction (NMJ). Dr. Charles Krieger has observed that a substance called adducin, which is critical to the structure of the NMJ, is altered in…

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Mechanisms of in vitro synaptic transmission of mis-folded human SOD1

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    British Columbia

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to another. In…

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Generating expanded repeats in the C9ORF72 ortholog in zebrafish

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. To date, several key mutations that cause ALS in humans (SOD1, TDP-43, FUS, etc.) have been introduced to zebrafish resulting in motor neuron dysfunction and and paralysis.…

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