721 results found
Genomic markers of cerebral small vessel ischemia
Project Overview
The overall goal of this research program is to identify genomic markers that predict small vessel disease of the brain. Specifically we will investigate patients that have had strokes or dementia due to small vessel disease, or who have brain imaging showing evidence of damage to the small blood vessels…
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See the project and researchersNeuroinflammatory susceptibility to vascular disease as a dementia driver
Project Overview
Recent studies have shown that damage to the small blood vessels in the brain (cerebrovascular disease) may increase the risk for Alzheimer’s. However, not everyone with small vessel damage develops memory problems, suggesting there are other factors that mediate this risk. Since brain inflammation is a key characteristic of both…
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See the project and researchersSleep, cognition, and inflammation following natural or surgical menopause
Project Overview
Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences. A woman’s brain health, for example, may be affected more strongly than a man’s by the presence of APOE-e4, a gene variant linked to Alzheimer’s risk. Nicole Gervais, Ph.D.,…
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See the project and researchersPreventing Language Decline in Dementia
Project Overview
Primary progressive aphasia (PPA) is a form of dementia which impairs the ability to understand spoken and written language but other cognitive skills (including memory) remain intact for several years after its onset. Ideally, interventions to improve communication abilities in people with PPA would begin during the earliest stages when…
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See the project and researchersThe Automated Monitoring of Gait as a Predictor of Fall Risk
Project Overview
People with dementia are at a high risk for falls which are a leading cause of injury and can contribute to loss of independence and quality of life. Many falls could be prevented if there was a way to predict an individual’s likelihood of falling and offer interventions to reduce…