740 results found
Mechanisms of delayed death in stroke
Project Overview
Stroke is a major cause of death and disability. At present, there are no clear and effective therapies to aid the majority of patients who suffer stroke. The goals of the present research are to understand the stroke process and identify targets, which block brain cell death following an ischemic…
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See the project and researchersRole of ATF4 and P53 family transcription factors in the regulation of neuronal cell death
Project Overview
Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Brain cell death following stroke leads to the loss of brain controlled functions such as speech and locomotion. Unfortunately, the factors that control brain cell death during stroke have not…
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See the project and researchersSynaptic mechanisms in post-stroke depression
Project Overview
Stroke affects 17% of people worldwide and some estimates predict that it will soon become the most common cause of death worldwide. Post-stroke depression impacts a significant portion of patients that suffered from a stroke. The consequences of post-stroke are immense and are a severe impairment in the path to…
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See the project and researchersHabitual physical activity, exercise and cardiovascular function in spinal cord injury
Project Overview
The major objectives of this research program are to measure the function of the heart and blood vessels following SCI and to investigate the mechanisms that are responsible for any changes that occur. A second objective is to examine the effect that both physical activity, which describes any bodily movement,…
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See the project and researchersGenomic markers of cerebral small vessel ischemia
Project Overview
The overall goal of this research program is to identify genomic markers that predict small vessel disease of the brain. Specifically we will investigate patients that have had strokes or dementia due to small vessel disease, or who have brain imaging showing evidence of damage to the small blood vessels…