Skip to content
Project Directory
  • Français
Donate Now
  • Français
  • About
    • What We Do
    • Leadership
    • Team
    • Publications
    • Careers
  • Diseases/Disorders
    • One Brain
    • ALS
    • Alzheimer’s
    • Autism
    • Brain Cancer
    • Brain Injury
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • Other
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
  • Ways To Give
    • Your Impact
    • How You Can Help
    • Events

Funded Grants

Back to results

Role of ATF4 and P53 family transcription factors in the regulation of neuronal cell death

Project Overview

Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Brain cell death following stroke leads to the loss of brain controlled functions such as speech and locomotion. Unfortunately, the factors that control brain cell death during stroke have not been identified. The overall objective of this research project is to identify the factors within brain cells that determine whether they will live or die following a stroke. Dr. Cregan and his team have identified pro-death factors that are activated during brain ischemia(stroke) and in this research project they will determine whether blocking these factors protects brain cells in stroke. They have developed models to mimic stroke conditions in isolated brain cells and mice. They will use drugs and genetic approaches to block the function of potential pro-death factors and determine whether this prevents the brain cells from dying during stroke conditions. Their research is directly aimed at identifying those factors that are involved in regulating brain cell death in stroke. Their research could lead to the identification of novel drug targets to reduce brain damage and minimize functional deficits in individuals affected by stroke.

Principal Investigator

Sean Cregan , University of Western Ontario

Partners and Donors

Heart and Stroke Foundation

Project Ongoing

Role of ATF4 and P53 family transcription factors in the regulation of neuronal cell death

  • Program Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Heart and Stroke Foundation Grant-in-Aid

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $256,200

  • Health Canada Contribution

    $128,100

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Playing with Marbles Podcast

Join us and take a journey to the real last great frontier – the brain.

Listen

Subscribe to Brain News

Receive our monthly electronic newsletter with updates on funded projects, upcoming events and breakthroughs in brain research.

Sign up

© 2023 Brain Canada Foundation

Registration number: 89105 2094 RR0001

  • Terms and Conditions
  • Privacy Policy

Design by Field Trip & Co