695 results found
Treatment strategies for Autism Spectrum Disorders and Fragile-X Syndrome using mouse models, via translational control modulators
Project Overview
Aberrant control of protein synthesis (also termed translation) leads to pathological conditions like cancer, obesity, memory impairment and has been hypothesized to cause the development of Autism Spectrum Disorders (ASD) and Fragile-X syndrome (FXS). Synaptic connections are regulated by translation, thus impaired translational control is postulated to cause ASD. It…
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See the project and researchersCorrection of Neuronal Function in Autism
Project Overview
The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a yearly basis and new interventional strategies are required to treat ASDs and related disorders like Fragile X syndrome. Altered communication between brain cells may lead to the defects responsible for the features that characterize autism and other neurodevelopmental…
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See the project and researchersRestoration of visual function: a cellular reprogramming and bioengineering approach
Project Overview
The retina is the part of the eye that is responsible for processing visual information. Loss of neurons (nerve cells) in the central nervous system, which includes the brain and retina, is a particularly serious problem because, with few exceptions, these neurons do not regrow after they are lost in…
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See the project and researchersNeuronal polarity defects as an underlying cause of neurological diseases.
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Neurons are cells with long extensions that send information from one part of the nervous system to another. Two types of neural extensions exist: the dendrites, which receive the information and the axon, which carry the information to other parts of the nervous system. The structures responsible for neurons to…
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See the project and researchersEpigenetics and mental health: the Canadian neuroepigenetics network
Project Overview
Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism that divided researchers who emphasized the importance of environmental influences from those who considered the importance of heritable variation in the genome. This was never…