Directory of funded grants

Impact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence

Project Overview

Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in metabolic pathways confer altered metabolic function by increasing production of the oncogenic metabolite R-2-Hydroxyglutarate (R-2HG). This metabolite was shown to promote…

Specific translation of mRNAs encoding primary cilia components as a new resistance mechanism in glioblastoma

Project Overview

We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments. Our team developed a new technique to analyze a specific part of the tumour's molecular makeup and found three subtypes with different survival rates. One subtype, called "Ciliary," stands out because of…

Identification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging

Brain-heart dynamics in treatment-resistant depression and the effects of repetitive transcranial magnetic stimulation

Defective protein translation: a causative pathway in ALS