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676 results found

Determining the contribution of acute viral infection on the onset and progression of ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $25,000

Project Overview

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…

Project Ongoing

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Defective protein translation: a causative pathway in ALS?

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $75,000

Project Overview

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…

Project Ongoing

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Development of a shared decision-making aid for bulbar symptom management in ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $50,000

Project Overview

Bulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients. It is characterized by a rapid progression, short survival after diagnosis, and poorer quality of life. Clinical management of bulbar symptoms is focused on optimizing patients’ function and…

Project Ongoing

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Resetting Microglia Activation in Offspring Exposed to Maternal High-Fat Diet

  • Grant Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    Master's Personnel Awards for Black Scholars

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $50,000

Project Overview

Nutrition and diet are factors in life that contribute drastically to a person’s brain health, and overall quality of life, and high-fat diets can be considered a cause of many harmful physical and cognitive conditions. In rodent models, exposing the mother to a high-fat diet has been shown to negatively…

Project Ongoing

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Sex-related differences in visuomotor skills, cognition, and emotionality following concussive injury

  • Grant Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Brain Injury

  • Competition

    Master's Personnel Awards for Black Scholars

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $10,000

Project Overview

The proposed research project aims to study the differences in brain function behaviour between male and female university athletes who have experienced a concussion. The research will examine hand-eye coordination, thinking and mental processing, and feelings and emotions of these athletes. The research will also investigate the impact of concussion…

Project Ongoing

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