720 results found
A prodepressive dopamine receptor complex in brain mediates sex differences in depression and anxiety: validation and strategies for drug discovery
Project Overview
Major depression is common, highly prevalent, potentially lethal, affecting 10% of individuals with significant increase between 2015-2020, and 2-3-fold higher incidence in women compared to men. No cause for this sex difference is known, nor is it addressed by available treatments. Current antidepressants targeting serotonin/noradrenergic systems are ineffective in many,…
Project Ongoing
See the project and researchersDeveloping open-science resources to map transgenerational, sex-specific effects of peripartum neuropsychiatric disease
Project Overview
Pregnancy and the postpartum period are high risk for depression onset and other psychiatric disorders in the birthing parent. Up to 20% of females experience postpartum depression, which not only impacts maternal health, but has transgenerational impact on children’s neurodevelopmental and mental health risk. Boys are more likely to develop…
Project Ongoing
See the project and researchersInsulin resistance in the mesolimbic system, a novel hypothesis for depression associated with metabolic resistance from obesity.
Project Overview
Depression and anxiety are highly prevalent in people with obesity and type 2 diabetes. There are several theories of the cause of this association, however one commonality amongst these theories is that insulin, a hormone released after meals, becomes ineffective in obesity or type 2 diabetes and no longer regulates…
Project Ongoing
See the project and researchersSpatial-temporal determinants of NMJs: from genes to function
Project Overview
Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons, neurons that control the muscles to generate fundamental movements in our daily life, are gradually destroyed during the disease leading to paralysis and eventually death. However, the death of motor neurons is preceded by the destruction of their contact with…
Project Ongoing
See the project and researchersRelevance of stress granule dynamics to ALS pathogenesis in vivo
Project Overview
Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment. The disease affects motor neurons, which are nerve cells that control the voluntary movement of muscles. These cells are under constant stress in ALS patients and eventually die, resulting…