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Investigating localized proteostasis to sustain synaptic plasticity

  • Grant Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

The mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Synapses are plastic and adapt their macromolecule composition and structure to the stimulus they receive. The essential macromolecules for synapses to function are proteins. The synthesis of proteins at synapsis is critical to reinforce connections…

Exploring the role of ectosomes in Parkinson’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2023

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Parkinson’s disease is a neurodegenerative movement disorder. At the cellular level, one of the main features of Parkinson’s disease is the clumping of a protein called alpha-synuclein. The disease gets worse as this clumping phenomenon spreads from one neuron to the next. A second feature of Parkinson’s disease is defects…

The role of inhibition in shaping neuronal memory traces in health and schizophrenia

  • Grant Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

We remember our experiences in the correct order and we can assess the elapsed time between them. Patients with damage in the hippocampus brain region cannot remember the order and time of experienced events, even though they can remember those events. Therefore, the hippocampus links together memories close in time,…

Prioritizing Progressive Supranuclear Palsy: a transformative in vivo model of disease pathogenesis with strong translational value for future drug development

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Progressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. By studying the brains of patients who have died scientists have discovered that PSP brains contain toxic deposits of a protein called tau. Tau deposits in PSP brain are seen in both nerve cells and support…

Investigation of Cerebrovascular Disease across Sexes and Neurodegenerative Disorders through Post-mortem Imaging and Histology

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. In over 75% of the cases, there is evidence of damage to the blood vessels in the brain. We can study these vascular brain damages using magnetic resonance imaging…