682 results found
A Drug Screening Assay to Reduce LINGO-1 Amounts in Neurons
Project Overview
The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. LINGO-1 is a transmembrane protein that negatively regulates neuronal survival and myelination. LINGO-1 inhibition increases survival of multiple neural types and improves spatial learning, memory, and cognitive abilities in multiple mouse models. Thus, we hypothesize…
Project Ongoing
See the project and researchersCognitive training platform to revolutionize healthcare for people with concussions
Project Overview
Led by Dr. Jocelyn Faubert from the Université de Montréal in collaboration with Neurotracker Athletics Inc., this project includes an inter-provincial research collaboration with Prof. Brian Christie and Prof. Jodie Gawryluk from the University of Victoria. Awarded through the CQDM-Brain Canada Joint Call for Collaborative Research Projects on the Brain…
Project Ongoing
See the project and researchersA novel immunotherapy based on genetically modified hematopoietic stem cells as a new hope for treating glioblastoma, an aggressive cancerous tumor of the brain
Project Overview
Led by Dr. Elie Haddad from CHU Sainte-Justine in collaboration with Immugenia, this project includes an inter-provincial research collaboration with Prof. Scott McComb and Prof. Anna Jezierski of the National Research Council of Canada (NRC) and the University of Ottawa who are advancing research innovations through the NRC’s Disruptive Technology…
Project Ongoing
See the project and researchersThe application of 3D models to assess the role of microglia in neurodegenerative disorders
Project Overview
Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction. While microglia, the immune cells resident in the central nervous system,…
Project Ongoing
See the project and researchersPrecision Metabolism: Deciphering and Targeting Metabolic Adaptations in Therapy-Resistant Recurrent Glioblastoma
Project Overview
Glioblastoma (GBM) is a common and deadly brain cancer in adults. Doctors use strong medicine (chemotherapy) and special rays (radiation therapy) to treat it. However, 80-90% of patients see the cancer come back, and the usual treatments don't work anymore. This project aims to find out why GBM comes back…