721 results found
PET imaging of Alzheimer’s-induced inflammation to monitor progression and therapy response using a novel fructose-based radiotracer
Project Overview
Alzheimer's Disease (AD) is tough to diagnose as it requires understanding patient history, symptoms, blood tests,and brain scans. Current brain scans mainly look at how glucose and amyloid (a protein) behave, but these tests aren't very reliable. Researchers aim to create a new brain scan that can better identify AD…
Project Ongoing
See the project and researchersDeep histological and pathological phenotyping of sporadic dementia
Project Overview
Patients with dementia may have pure Alzheimer Disease (AD) pathology or a combination of pathologies called mixed dementia. In general, patients with younger age of onset (less than 65 years) tend to exhibit pure AD pathology, whereas older individuals are more likely to develop mixed dementia. Among the most common…
Project Ongoing
See the project and researchersSignatures of early life stress as a risk factor for Alzheimer’s disease
Project Overview
Childhood stress increases the risk of Alzheimer’s Disease (AD). Early signs of AD appear in a part of the brain that produces serotonin, a chemical important for mood and memory-both of which are affected in AD. Serotonin is also sensitive to childhood trauma. Although there is a connection between early…
Project Ongoing
See the project and researchersEnsuring equitable access to inpatient rehabilitation for people living with dementia: An effectiveness-implementation randomized trial
Project Overview
One in five older adults with dementia is hospitalized each year. One in three hospitalized older adults will lose independence in transferring, eating, ambulating, dressing, or bathing, which increases nursing home admission risk; this risk is 36% greater in people living with dementia (PLWD). Rehabilitation could decrease this risk, but…
Project Ongoing
See the project and researchersA Pilot Randomized Trial of a Digital App, WhatMatters to enable Person-Centred Care
Project Overview
Person-centred care is critical in supporting people with dementia, particularly in hospital settings where unmet needs can lead to responsive behaviors such as confusion and agitation. These behaviours are often caused by stress and are preventable through personalized, non-pharmacological interventions. WhatMatters is a digital app designed to support person-centred care…