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661 results found

Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $30,692

  • Health Canada Contribution

    $15,346

Project Overview

A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis. He then tested them with a battery of potential treatments to see if they could find one that would have a positive effect on motor neuron…

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Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract. Other specialized neurons inhibit these signals, allowing muscles to relax. When this inhibitory process does not occur, motor neurons become overexcited, a hallmark feature of ALS before symptoms appear, particularly in the upper…

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Characterizing Enterovirus Disruption of Autophagy as a Disease Mechanism for ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    British Columbia

  • Start Date

    2018

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes. However, some enteroviruses are more serious, like enterovirus D68 that can cause severe respiratory illnesses or the poliovirus that causes…

Project Complete

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Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Ontario

  • Start Date

    2018

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly. In the majority of ALS cases, a protein known as TDP-43 becomes misfolded and accumulates in motor neurons, causing toxicity. The accumulation of misfolded TDP-43 also occurs in…

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MRI Biomarkers of Cerebral Degeneration in ALS and their Pathological Validation

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Alberta

  • Start Date

    2018

  • Total Grant Amount

    $21,875

  • Health Canada Contribution

    $10,938

Project Overview

A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps determine risk, severity and response to therapy. Today, biomarkers are being incorporated into an increasing number of clinical trials. They can help advance drug development by providing researchers a way to monitor…

Project Complete

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