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In vitro and in vivo functional assessment of neuropsychiatric disease-related synaptic gene mutations

  • Program Type

    Capacity building grants

  • Area of research

    Multiple

  • Disease Area

    Autism,  Mental illness

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    British Columbia

  • Start Date

    2016

  • Total Grant Amount

    $76,659

  • Health Canada Contribution

    $38,330

Project Overview

Dr. Xie’s research focuses on the functional assessment of neuropsychiatric disease related synaptic genes – MDGA1 and 2. MDGAs bind to critical neuron synaptic proteins – Neuroglin (NLGN), disrupting the binding between NLGN and Neurexin (NRXN), so suppressing synaptogenesis. Mutations (missense or truncation) of MDGA1 and 2 have been found…

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Recruitment of Endogenous Neural Stem Cells to Promote Brain Repair Following Acquired Brain Injury in Children

  • Program Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Brain Injury

  • Competition

    W. Garfield Weston Foundation – Brain Canada Multi-Investigator Research Initiative (MIRI)

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $150,000

  • Health Canada Contribution

    $75,000

Project Overview

In Canada, over 140,000 children and teenagers suffer a brain injury each year due to trauma, stroke, cerebral palsy, and brain cancer. Children are often left with permanent physical, psychological, and neurological problems. Currently, there are no effective medical therapies to help brain recovery and reduce disability following an acquired…

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The role of attention control and emotional regulation in the emergence of autism spectrum disorder (ASD): Identifying early behavioral markers of ASD in at-risk infants

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $70,000

  • Health Canada Contribution

    $35,000

Project Overview

Ms. Raza’s research focuses on early development in autism spectrum disorder (ASD), with the goal of identifying behavioral and physiological markers in at-risk infants. She is interested in the role early attention and emotional regulation play in the emergence of autism, and anticipate that my research will shed light on…

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A multi-platform approach to the functional assessment of ASD gene variants

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    British Columbia

  • Start Date

    2016

  • Total Grant Amount

    $70,000

  • Health Canada Contribution

    $35,000

Project Overview

The high and potentially increasing prevalence of Autism Spectrum Disorder (ASD) is taking a significant emotional and economic toll on patients, their families and Canadian society. Although progress has been made in identifying genes associated with ASD, the underlying mechanism of this disorder remains unknown. Recently, several exome-sequencing studies of…

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Impaired translational regulation of brain development in autism spectrum disorders

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $110,000

  • Health Canada Contribution

    $55,000

Project Overview

Autism spectrum disorders (ASDs) are a group of complex neurodevelopmental disorders with distinguished early emerging behavioral disruptions (speech impairments, social communication, repetitive behaviors) and a rising rate of diagnosis to an estimated 1 in 68 children. Synaptogenesis occurs in the vertebrate central nervous system from early embryonic life to adulthood.…

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