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551 results found

Immunotherapy as a targeted low-impact treatment of paediatric brain cancers

  • Program Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $110,000

  • Health Canada Contribution

    $55,000

Project Overview

The existing treatment regimens for children with ependymomas are generally not successful and if successful survivors are left with considerable disabilities including severely diminished IQ, focal neurological and language deficits, and endocrine deficiencies. Dr. Donovan's current proposal aims to develop an improved targeted therapy, which will increase survival rates, and…

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Investigating Blood Brain Barrier Permeability in an Experimental Model of Juvenile Stroke Using Advanced MR Imaging

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $110,000

  • Health Canada Contribution

    $55,000

Project Overview

Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences.  Currently, treatment of childhood stroke is limited to prevention of more strokes.  Dr. Domi’s research uses specialized imaging techniques to study the role of the blood-brain barrier, a mechanism…

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The Effects of Glucocorticoids on the Developing Brain

  • Program Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $70,000

  • Health Canada Contribution

    $35,000

Project Overview

The hippocampus has the highest concentration of glucocorticoid receptors in the brain, and is therefore a primary target for glucocorticoids. The fetus may be exposed to increased levels of glucocorticoids as a result of maternal stress/anxiety, or by maternal treatment with synthetic glucocorticoids (sGC); ~10% of all pregnant women are…

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Maternal care and child neurodevelopment: A longitudinal gene x environment analysis of socio-emotional development with an integrated approach

  • Program Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $60,000

  • Health Canada Contribution

    $30,000

Project Overview

Maternal depression, particularly during pregnancy, has been well established as a risk factor for child socio-emotional problems. However, the impact varies across the population, as some individuals are resilient. Their genetic architecture may hold the secrets to the differential susceptibility. Mr. Chen’s research looks at how genomic risk profile for…

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Development of novel oligonucleotide delivery modalities for Huntington disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    Brain Canada-Huntington Society of Canada Creating HD Clinician-Scientist-to-Patient Virtual Networks Multi-Investigator Research Initiative (MIRI)

  • Province

    British Columbia

  • Start Date

    2017

  • Total Grant Amount

    $950,000

  • Health Canada Contribution

    $475,000

Project Overview

Huntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world. The cause of HD is a mutation in one copy of the HTT gene, which produces the toxic mutant huntingtin protein responsible for the brain cell loss associated with the disease.…

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