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587 results found

Drug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - CIBC Brain Cancer Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Although it is now known that miRNAs act in part via post-transcriptional effects on mRNA stability and/or translation to modulate gene expression, other molecular mechanisms by which non-coding RNAs may effect changes in mRNA and protein expression remains poorly elucidated. Specifically, it remains unknown whether miRNAs and LncRNAs, have other…

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Season, Light Exposure and Serotonin Transporter Binding

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Mental Health Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $105,000

  • Health Canada Contribution

    $52,500

Project Overview

The serotonin transporter (5-HTT) is a protein that clears extracellular serotonin from the synapses and depletion of serotonin is associated with depressive symptoms. Previously, in healthy individuals, we discovered that 5-HTT BPNo, an index of 5-HTT levels, was greater in affect-modulating brain regions in the fall/winter compared to the spring/summer;…

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The effects of optogenetically activated orexin/hypocretin neurons on the mesolimbic reward pathway

  • Grant Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Mental illness

  • Competition

    Bell Mental Health Research Training Awards

  • Province

    British Columbia

  • Start Date

    2013

  • Total Grant Amount

    $105,000

  • Health Canada Contribution

    $52,500

Project Overview

Mr. Baimel’s work focuses upon the role of the neuropeptide, orexin, and its role in modulating the neural region which regulates reward sensations, the ventral tegmental area (VTA). The primary objective of his work was to examine alterations in synaptic transmission in the VTA in response to addictive drugs. Mr.…

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The Role of Translational Control in Cortical Dysgenesis in Mammalian Brain

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Bell Mental Health Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Abnormal development of neural circuitry is thought to be the major cause of autism and many other mental illnesses. However, we still don’t understand the cellular mechanisms that result in these alterations, and the underlying genetic and/or environmental causes are still unclear. In this regard, recent evidence from the Miller…

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The role of immune genes in schizophrenia

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Mental Health Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $105,000

  • Health Canada Contribution

    $52,500

Project Overview

Schizophrenia (SCZ) is ranked among the top ten illnesses contributing to the global burden of disease, yet its etiology is still poorly understood. The neuroinflammatory hypothesis of SCZ is rooted in evidence that prenatal infection triggers an immune-mediated inflammatory response in the fetal brain, disrupting neurodevelopment and increasing SCZ risk.…

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