720 results found
Mapping neuronal circuits using a novel transsynaptic labelling approach
Project Overview
The brain is more than the sum of its parts. Truly understanding the brain's most intricate properties requires both a list of its individual parts, that is a census of the types of neurons it contains, and a map of how these parts are interconnected to form neural circuits. Hundreds…
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See the project and researchersTanycytic structural plasticity in circumventricular organs underlies homeostatic brain-body communication
Project Overview
Metabolic syndrome is a group of risk factors (obesity, hypertension, high fasting blood sugar, and high levels of triglycerides) that increase the risk of type 2 diabetes and cardiovascular diseases. Over 20% of adult Canadians suffer from metabolic syndrome (40% in adults over 60 years old), and effective treatments are…
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See the project and researchersLaminar regulation of hemodynamics in primary auditory cortex
Project Overview
Brain disorders and disease represent an immense societal burden and the leading cost to the Canadian health care system. Although research in animal models has led to major advances in our understanding of brain function and dysfunction at the cellular level, a major challenge remains bridging these findings from animals…
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See the project and researchersA Human System to study Immune-Ependymal Cell Relationships
Project Overview
Ependymal cells are a largely understudied barrier cell type in the brain that provide a wall between brain tissue and brain fluid (cerebral spinal fluid, CSF), playing an important role in regulating fluid balance. These cells become dysfunctional in many brain diseases and this dysfunction contributes to neurodegeneration that occurs…
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See the project and researchersDetection of tandem repeat expansion in neurological disorders
Project Overview
In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. It has improved clinical diagnosis and gene discovery for numerous human brain disorders. However, the casual genetic risk factors identified so far generally confer less risk than expected…