721 results found
Neurodegenerative potential for microglia in a progressive MS model
Project Overview
Multiple Sclerosis (MS) is a disease where the immune system attacks the brain and spinal cord. The resulting disability can range from vision loss in one eye or complete paralysis. After years of suffering from this disease, most people enter a phase called progressive MS where available treatments are no…
Project Complete
See the project and researchersHippocampal heterogeneity in health and disease
Project Overview
The brain is estimated to contain 100 billion cells that form 100 trillion connections. Brain cells speak to each other by releasing chemicals into a small area known as the synapse, and neighboring cells can listen by using their ability to sense these chemicals. Like our daily conversations, brain cell…
Project Ongoing
See the project and researchersElectrically guided transcranial stimulation of cells chemogenically primed for excitability a novel, non-invasive and cell type-specific approach
Project Overview
Dr Bambico proposes to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic techniques. This will be done…
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See the project and researchersThe influence of functional connectivity on cognitive reserve
Project Overview
Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain injuries as well as with normal aging despite any clear pathological condition. With normal aging, there is a diverse spectrum of cognitive decline with some individuals showing strong impairments while others show very little loss in cognitive ability.…
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See the project and researchersBrain pericyte calcium signaling during vasomotion and neurovascular coupling
Project Overview
The brain requires a large amount of energy and oxygen for survival. In order to meet these requirements, the blood supply to the brain is tightly controlled to ensure that active areas receive more blood. Recently, cells known as pericytes, which are found on small blood vessels, were shown to…